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Tubulin inhibitor 35
CAS No. 2247047-77-2
Tubulin inhibitor 35( —— )
Catalog No. M36970 CAS No. 2247047-77-2
Tubulin inhibitor 35 (Tubulin IN 35) is a potent dual inhibitor of topoisomerase I and microtubule protein polymerization with antitumor activity, inhibits migration and invasion of MGC-803 and RKO cell lines, interrupts the cell cycle and induces apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 82 | Get Quote |
|
| 5MG | 120 | Get Quote |
|
| 10MG | 176 | Get Quote |
|
| 25MG | 273 | Get Quote |
|
| 50MG | 421 | Get Quote |
|
| 100MG | 601 | Get Quote |
|
| 500MG | 2115 | Get Quote |
|
| 1G | 2907 | Get Quote |
|
Biological Information
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Product NameTubulin inhibitor 35
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NoteResearch use only, not for human use.
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Brief DescriptionTubulin inhibitor 35 (Tubulin IN 35) is a potent dual inhibitor of topoisomerase I and microtubule protein polymerization with antitumor activity, inhibits migration and invasion of MGC-803 and RKO cell lines, interrupts the cell cycle and induces apoptosis.
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DescriptionTubulin inhibitor 35 (compound 6b) is a dual inhibitor of topoisomerase I (IC50=~50 μM) and tubulin polymerization (IC50=5.69 μM). Tubulin inhibitor 35 inhibits migration and invasion of MGC-803 and RKO cell lines，and induces apoptosis via arresting cell cycle at G2/M phase. Tubulin inhibitor 35 exhibis potent efficacy in gastrointestinal tumor inhibiton (inhibits MGC-803 (IC50=0.09 μM) and RKO (IC50=0.2 μM) cell lines).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetTopoisomerase
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RecptorTopoisomerase | Microtubule Associated | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number2247047-77-2
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Formula Weight331.41
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Molecular FormulaC21H21N3O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C=2C=CC=CC2N(CCC)C3C=4NC=5C=CC=CC5C4CCN13
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Deng J, et al. N(14)-substituted evodiamine derivatives as dual topoisomerase 1/tubulin-Inhibiting anti-gastrointestinal tumor agents. Eur J Med Chem. 2023 Jul 5;255:115366.?
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